FRACTAL STORM (SELF-LAID OPTIONS

In the LSD-bound crystal framework, the side chain from the lid residue L209EL2 varieties considerable hydrophobic contacts with both LSD and bordering residues in TMs III, IV, and V (Determine 4C). Once the lid moved apart to reveal the binding pocket in simulation, various of those contacts broke. We thus hypothesized that L209EL2 acts being a la